Substance use and psychiatric outcomes following substance use disorder treatment: An 18-month prospective cohort study in Chile.
Evidence from high-income countries has linked duration and compliance with treatment for substance use disorders (SUDs) with reductions in substance use and improvements in mental health. Generalizing these findings to […]
Examining the risk of delirium in patients hospitalized with COVID-19: Insights from the homeless population.
For patients hospitalized with COVID-19, delirium is a serious and under-recognized complication, and people experiencing homelessness (PEH) may be at greater risk. This retrospective cohort study compared delirium-associated risk factors […]
Examining the association between fentanyl use and perceived adequacy of methadone dose: A retrospective cohort study.
People exposed to fentanyl may report that the dose of methadone in the commonly accepted therapeutic range feels too low. We examined self-reported methadone dose adequacy. We conducted a retrospective […]
Pharmacological treatment for substance use disorder: A systematic review.
There is strong evidence of the substance dependence has a negative impact on key dimensions of health. The scientific evidence suggests that pharmacological treatment could play a fundamental role in […]
Impulsivity behaviors and white matter mediate the relationship between genetic risk for cannabis use disorder and early cannabis use in adolescents.
Cannabis use disorder (CUD) is strongly influenced by genetic factors; however the mechanisms underpinning this association are not well understood. This study investigated whether a polygenic risk score (PRS) based […]
Cannabis use and atherosclerotic cardiovascular disease outcomes: A meta-analysis of multinational cohort data.
While an association between cannabis use and the risk of atherosclerotic cardiovascular diseases (ASCVD) has been reported numerous times, it remains inconclusive as to whether this link is causal in […]
Alcohol and substance use differentially impact suicidal ideation in a longitudinal cohort of bipolar disorder.
Across bipolar disorders (BSDs), alcohol and substance use and suicidal ideation (SI) contribute to increased rates of morbidity and mortality. The goal of the present study was to investigate temporal […]
Epidemiology of New Psychoactive Substances in Relation to Traditional Drugs of Abuse in Clinical Oral Fluid Samples.
New psychoactive substances (NPS) are health-hazardous through unpredictable toxicity and effects and largely unknown epidemiology, motivating studies of the latter. Up to 138 NPS were retrospectively identified using liquid chromatography-high […]
Prognostic impact of chronic obstructive pulmonary disease on short-term and long-term outcomes following coronary artery bypass grafting.
Chronic obstructive pulmonary disease (COPD) is a common condition that complicates major surgeries like coronary artery bypass grafting (CABG). This study aims to evaluate the impact of COPD on the […]
Baseline Participant Characteristics are Associated With Engagement in a Movement-Based RCT for Chronic Low-Back Pain.
PurposeExamine whether baseline participant characteristics predict engagement in a movement-based RCT for chronic low back pain (CLBP).DesignLongitudinal study within an RCT.SettingOnline.Subjects138 individuals with CLBP (18-79 years).InterventionParticipants were randomized to a […]
Factors Associated With Cocaine Use at 17 and 20 Years Old: A Longitudinal Analysis of a Nationally Representative Cohort.
Despite growing concerns about trends in cocaine use, there is a shortage of longitudinal research that prospectively examines risk and protective factors associated with cocaine initiation and use in general […]
App-Based Coaching to Prevent Addictive Behaviors in Vocational School Students: A Cluster Randomized Trial.
This two-arm cluster randomized controlled trial evaluated the effectiveness of an app-based addiction prevention program in German vocational school students. Schools from 5 German federal states were recruited. No eligibility […]
Cannabis use in Crohn’s disease: a systematic review and meta-analysis of randomized controlled trials (RCTs).
This meta-analysis aims to systematically evaluate the efficacy and safety of cannabis in the management of Crohn’s disease (CD) by synthesizing evidence from randomized controlled trials (RCTs). By adhering to […]
A network analysis of clinician-rated posttraumatic stress disorder and substance use disorder symptom clusters in a sample of veterans seeking outpatient treatment.
The presentation of comorbid post-traumatic stress disorder (PTSD) and substance use disorder (SUD) differs by substance type. The current study applied network analysis to explore the relationships between diagnostic symptom […]
Oral lesions and disorders and their prevalence arising from the use of illicit drugs in a prison population.
The dependence on the illicit drugs has been proven to be harmful to the oral cavity and may lead to a series of abnormal manifestations. The main objective of this […]
Clinician’s perceptions and experiences with tobacco treatment in people who use cannabis: a qualitative study.
Global demand for the treatment of cannabis use disorder has increased significantly, prompting a need to understand effective strategies for addressing concurrent cannabis and tobacco use. This study focuses on […]
Mitochondrial DNA variants and their impact on epigenetic and biological aging in young adulthood.
The pace of biological aging varies between people independently of chronological age and mitochondria dysfunction is a key hallmark of biological aging. We hypothesized that higher functional impact (FI) score […]
Longitudinal evolution of the transdiagnostic prodrome to severe mental disorders: a dynamic temporal network analysis informed by natural language processing and electronic health records.
Modelling the prodrome to severe mental disorders (SMD), including unipolar mood disorders (UMD), bipolar mood disorders (BMD) and psychotic disorders (PSY), should consider both the evolution and interactions of symptoms […]